Cosmetic biofermentation a revolution in efficacy
Biofermentation has become one of the most relevant axes of innovation in the cosmetic industry.
This biotechnological process allows the development of actives with greater bioavailability, proven efficacy and a sustainable profile. Discover how postbiotics are redefining formulation for skin and hair.
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Cyanage
Vineactyl
- What is biofermentation and why is it transforming cosmetics?
Biofermented active ingredients from Cobiosa
Advantages for the formulator
Biofermentation: why it's transforming cosmetics
The global microbiome-based skincare market reached $434.8 million in 2024, with a projected value of $835.2 million by 2030 and a compound annual growth rate of 12.2%. This expansion reflects a structural shift in which skin bacteria are perceived as allies.
From fermentation to biofermentation
Traditional fermentation uses microorganisms to transform raw materials into bioactive compounds such as amino acids, peptides, or organic acids. Biofermentation is its evolution: a controlled process with specific strains and optimized pH, temperature, and substrate to produce high-value cosmetic molecules in a targeted way.
Biotechnology and fermentation are the two major strategic bets for the cosmetics industry over the next five years. The clean biotech trend combines the efficacy of biotechnologically derived active ingredients with the sustainability and naturalness demanded by modern consumers. Biofermented active ingredients also reduce environmental impact compared to conventional extraction processes, aligning with brands' ESG objectives.
Why is biofermentation the cosmetic industry's big bet?
Biofermentation: next-generation cosmetic actives
Contents
Cobiosa's biofermented actives
Cobiosa applies biofermentation to develop actives with demonstrated clinical efficacy in two growing segments: skin longevity and scalp care. Both are water-soluble, 100% natural according to ISO 16128, vegan and preservative-free, with in vitro and in vivo data backing their performance.
Cyanage: skin longevity postbiotic
Cyanage is a Lactobacillus ferment lysate that acts on the Hallmarks of Aging. In vitro at 0.3% it demonstrated mitochondrial and telomere protection. In vivo with 20 women over 28 days at 3% it achieved -14.2% in wrinkles, +2.9% in firmness and +2.4% in elasticity (p<0.05).
Vineactyl: hair biofermented active
Vineactyl is a Vitis vinifera leaf extract fermented with Saccharomyces cerevisiae for scalp care. Its polyphenolic composition is up to four times higher than that of the unfermented extract. In vivo trials with 23 volunteers over 28 days showed a 33.4% increase in scalp hydration and a 26.4% increase in breakage resistance.
Advantages for the formulator
Biofermented actives offer tangible formulation benefits: greater cutaneous penetration through molecular size reduction, better tolerance in sensitive skin and a sustainable cosmetics profile aligned with current market demands.
Sustainability and effectiveness
Biofermentation allows upcycling strategies to be applied, revaluing plant by-products such as vine leaf. It operates under mild temperature and pressure conditions, reducing energy consumption compared to chemical synthesis. The result is ingredients with a lower environmental footprint and high bioavailability.
Request technical information
The Cobiosa technical team can provide product data sheets, formulation protocols, efficacy data and laboratory samples. Request access to the complete documentation on Cyanage and Vineactyl or download the technical guide on biofermentation in cosmetics.
Definition
Biofermentation combines biotechnology, clinical efficacy and sustainability for a new generation of cosmetic actives. Download the complete technical guide on biofermentation in cosmetics and contact Cobiosa to evaluate these solutions in your laboratory.