Hallmarks of Aging: A Framework for Organizing the Complexity of Aging
Aging is a complex, progressive, and multifactorial biological process characterized by a gradual loss of physiological integrity and of the body’s ability to maintain homeostasis and respond to stress. Rather than resulting from a single cause, it arises from the accumulation of multiple molecular and cellular alterations that develop over time.
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Dragon's Blood
Hallmarks of Aging: A framework for understanding the complexity of aging
Contents
- 1. From Anti-Aging to the Biology of Aging
2. Hallmarks of Aging: An Evolving Concept
3. Active Ingredients Targeting the Hallmarks of Aging
1. From Anti-Aging to the Biology of Aging
For years, anti-aging care has focused primarily on correcting its visible signs. Today, advances in our understanding of the biology of aging allow us to go one step further and explore the cellular and molecular mechanisms underlying these changes.
A Progressive Process That Affects Skin Function
In the skin, aging results in a gradual loss of homeostasis, regenerative capacity, and tissue function. Over time, these changes reduce the tissue’s ability to maintain its balance and respond effectively to internal and external stressors.
An Integrated View of Aging
Current research views aging as a network of closely interconnected processes, in which disruption of one mechanism can influence others. This perspective helps organize its complexity and forms the basis of the Hallmarks of Aging framework.
2. Hallmarks of Aging: An Evolving Concept
The Hallmarks of Aging provide a conceptual framework for understanding the main molecular and cellular mechanisms involved in aging. Since their initial description, this model has evolved alongside scientific advances, incorporating new processes and offering an increasingly comprehensive view of the complexity of aging.
From 9 to 12 Hallmarks of Aging
The original proposal, published in 2013, identified nine fundamental mechanisms of aging. Ten years later, the framework was updated to incorporate new processes, expanding to the 12 Hallmarks of Aging and reflecting an increasingly comprehensive and dynamic view of aging.
Three Groups to Understand Their Evolution
Currently, the Hallmarks of Aging are classified into primary, antagonistic, and integrative hallmarks. Primary hallmarks are associated with the accumulation of cellular damage; antagonistic hallmarks involve initially compensatory responses that may become detrimental over time; and integrative hallmarks emerge when damage exceeds the capacity of homeostatic mechanisms.
3. Active Ingredients Targeting the Hallmarks of Aging
Understanding these mechanisms opens up new possibilities in cosmetic formulation. Rather than addressing only a visible sign of aging, it becomes possible to select ingredients that target different biological processes associated with aging and develop more comprehensive skincare strategies.
DRAGON’S BLOOD: Powerful Multifunctional Regenerator
Obtained from the latex of Croton lechleri, DRAGON’S BLOOD targets 10 of the 12 Hallmarks of Aging. Its epigenetic activity is combined with regenerative, antioxidant, and anti-inflammaging effects, while also supporting skin barrier function and hydration.
CYANAGE: Postbiotic-powered skin longevity
CYANAGE is a postbiotic obtained through biofermentation with Lactobacillus plantarum that targets 4 of the 12 Hallmarks of Aging. It helps promote skin longevity, protects against telomere shortening, and contributes to reducing wrinkles while improving skin firmness and elasticity.
Definition
The Hallmarks of Aging allow us to move beyond a perspective focused solely on the visible signs of aging toward a deeper understanding of the mechanisms that drive them. This new approach opens the door to developing cosmetic formulations that act more comprehensively on skin longevity, regeneration, and balance.